In a medieval world where illness can lead to horrific and monstrous transformation, the Lazarus Order is mankind's final bastion, preventing uncontrollable chaos. Devout plague doctors have sacrificed their freedom in an oath to God, in exchange for supernatural abilities.

However, their powers come at a great cost—the more they use them, the more it consumes them until they fade to nothing. Despite this sacrifice, they live in servitude and dedication to protecting humanity from vampires, werewolves, Rattusvir (Rat-man disease), the undead, and other variants of “The First Sickness.”

Doctor Damien, a meek, middle-aged stickler for protocol, is sent to team up with Edward Talis, an older, opportunistic, charming veteran doctor. They respond to what seems to be a routine call to subdue and cure a Rattusvir, only to discover an omen that “The First Sickness” has set events in motion to destroy the Lazarus Order once and for all.

Will they unravel its machinations before their oaths consume them? Or will they continue down their path towards righteous self-destruction, unaware of what foul monsters scheme beneath their feet?